Fluvastatin Extended-Release Tablets and PCE Dispertab

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ask your doctor before using erythromycin together with fluvastatin. Using these medications together can increase your blood levels of fluvastatin and may cause a dangerous side effect on your muscles. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely take both medications. You should also watch for muscle symptoms and call the doctor if you have muscle pain, tenderness, or weakness, especially if you also have dark colored urine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Severe myopathy and rhabdomyolysis have been reported with concomitant use of HMG-CoA reductase inhibitors and erythromycin in severely ill patients. The suspected mechanism is inhibition of HMG-CoA reductase inhibitor metabolism by CYP450 3A4 isoenzymes.

MANAGEMENT: While these effects have not been reported with concomitant use of fluvastatin and erythromycin, alternative therapy should be considered. If patients do receive this combination, they should be instructed to report symptoms of muscular pain, weakness, tenderness, malaise, or fever. If such symptoms occur, creatine kinase should be measured. Fluvastatin and erythromycin should be discontinued if creatine kinase is elevated.

Fluvastatin Extended-Release Tablets

Generic Name: fluvastatin

Brand name: Lescol, Lescol XL

Synonyms: Fluvastatin

What is Fluvastatin Extended-Release Tablets?

PCE Dispertab

Generic Name: erythromycin

Brand name: EES. Granules, EES-400 Filmtab, EryPed 200, EryPed 400, Ery-Tab, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, PCE Dispertab, E. E. S, EryPed, Erythrocin, Erythromycin Filmtabs, Erythromycin Lactobionate - IV

Synonyms: PCE Dispertab (Oral), PCE, PCE (Oral)

What is PCE Dispertab?