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Fluvoxamine and Seldane

Determining the interaction of Fluvoxamine and Seldane and the possibility of their joint administration.

Check result:

Fluvoxamine <> Seldane

Relevance: 09.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Terfenadine is no longer on the market in the US. Do not take terfenadine with any other medication.

Professional:

GENERALLY AVOID: Fluvoxamine is an inhibitor of the CYP450 3A4 isoenzyme and may interfere with the metabolism of terfenadine and astemizole. The accumulation of terfenadine or astemizole could lead to severe or potentially fatal cardiotoxic reactions. The manufacturer recommends that fluvoxamine not be used with these drugs. However, one in vitro study suggests that fluvoxamine is a relatively weak inhibitor of the CYP450 3A4 pathway and at the usual doses is not likely to impair terfenadine clearance to a clinically significant degree.

MANAGEMENT: Caution is advised if these drugs are used together, particularly if fluvoxamine is given in high doses.

References

Vonmoltke LL, Greenblatt DJ, Duan SX, Harmatz JS, Wright CE, Shader RI "Inhibition of terfenadine metabolism in vitro by azole antifungal agents and by selective serotonin reuptake inhibitor antidepressants: relation to pharmacokinetic interactions in vivo." J Clin Psychopharmacol 16 (1996): 104-12
"Product Information. Luvox (fluvoxamine)." Solvay Pharmaceuticals Inc, Marietta, GA.

Fluvoxamine

Generic Name: fluvoxamine

Brand name: Luvox, Luvox CR

Synonyms: FluvoxaMINE

What is Fluvoxamine?

Seldane

Generic Name: terfenadine

Brand name: Seldane

Synonyms: n.a.

What is Seldane?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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