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Fluvoxamine ER Capsules and Tacrine

Determining the interaction of Fluvoxamine ER Capsules and Tacrine and the possibility of their joint administration.

Check result:

Fluvoxamine ER Capsules <> Tacrine

Relevance: 28.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using tacrine together with fluvoxaMINE. Using tacrine with fluvoxaMINE can increase your blood levels of tacrine. This combination may cause side effects such as nausea, vomiting, sweating and diarrhea. The risk of liver problems may also be increased. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: The combined use of tacrine and fluvoxamine may result in elevated tacrine plasma concentrations. The mechanism may be due to the inhibition of CYP450 1A2 metabolism by fluvoxamine.

MANAGEMENT: This combination should be avoided if possible. If coadministration is necessary, monitor for side effects, such as nausea, vomiting, sweating and diarrhea. The risk of hepatotoxicity may be increased. Fluoxetine, a selective serotonin inhibitor that is not metabolized by 1A2 may be a safer alternative.

References

Becquemont L, Ragueneau I, LeBot MA, Riche C, FunckBrentano C, Jaillon P "Influence of the CYP1A2 inhibitor fluvoxamine on tacrine pharmacokinetics in humans." Clin Pharmacol Ther 61 (1997): 619-27

Fluvoxamine ER Capsules

Generic Name: fluvoxamine

Brand name: Luvox, Luvox CR

Synonyms: Fluvoxamine

What is Fluvoxamine ER Capsules?

Tacrine

Generic Name: tacrine

Brand name:

Synonyms: Tacrine (Oral)

What is Tacrine?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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