Fluvoxamine Extended-Release Capsules and Melatonin
Determining the interaction of Fluvoxamine Extended-Release Capsules and Melatonin and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using melatonin together with fluvoxaMINE is not recommended. Combining these medications may significantly increase the blood levels and effects of melatonin. Your doctor may be able to prescribe alternative treatments that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: The concomitant administration of fluvoxamine may increase the serum concentration of melatonin. The mechanism is inhibition of CYP450 1A2 and 2C19-mediated hepatic metabolism. Coadministration increased melatonin AUC by 17-fold and maximum plasma concentration (Cmax) by 12-fold.
MANAGEMENT: Concomitant use should be avoided.
- Cerner Multum, Inc. "Australian Product Information." O 0
Generic Name: fluvoxamine
Brand name: Luvox, Luvox CR
Synonyms: Fluvoxamine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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