Fluvoxamine Maleate and Ropinirole Tablets
Determining the interaction of Fluvoxamine Maleate and Ropinirole Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using fluvoxaMINE together with rOPINIRole may increase the effects of rOPINIRole. This combination may cause nausea, vomiting, weakness, drowsiness, fainting, agitation, and confusion. You may need a dose adjustment if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with drugs that are inhibitors of CYP450 1A2 may increase the plasma concentrations of ropinirole, which is metabolized by the isoenzyme. Ciprofloxacin (500 mg twice a day), a known inhibitor of CYP450 1A2, has been reported to increase the peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of ropinirole (2 mg three times a day) by an average of 60% and 84%, respectively, in 12 study subjects. The possibility of prolonged and/or increased pharmacologic effects of ropinirole should be considered.
MANAGEMENT: Pharmacologic response to ropinirole should be monitored more closely whenever a CYP450 1A2 inhibitor is added to or withdrawn from therapy, and the ropinirole dosage adjusted as necessary. Patients should be advised to contact their physician if they experience excessive adverse effects of ropinirole such as agitation, hallucinations, orthostasis, sedation, confusion, or increased dyskinesia, flushing, dry mouth, sweating, and heart rate.
- "Product Information. Noroxin (norfloxacin)." Merck & Co, Inc, West Point, PA.
- "Product Information. Requip (ropinirole)." SmithKline Beecham, Philadelphia, PA.
Generic Name: fluvoxamine
Brand name: Luvox, Luvox CR
Synonyms: Fluvoxamine
Generic Name: ropinirole
Brand name: Requip, Requip XL, ReQuip Follow on Pack, ReQuip Starter Pack, Repreve, Requip Starter Kit
Synonyms: Ropinirole, ROPINIRole
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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