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Fluvoxamine Tablets and Tegretol

Determining the interaction of Fluvoxamine Tablets and Tegretol and the possibility of their joint administration.

Check result:
Fluvoxamine Tablets <> Tegretol
Relevance: 05.10.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using carBAMazepine together with fluvoxaMINE may increase the effects of carBAMazepine. Contact your doctor if you experience shallow breathing, fast heartbeat, nausea, vomiting, urinating less or not at all, muscle twitches, restlessness, tremors, slurred speech, staggering walk, and feeling light-headed or fainting. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: When fluvoxamine is administered with carbamazepine, plasma carbamazepine levels may be increased and toxicity could result. It is suspected that the mechanism is related to inhibition of CYP450 hepatic metabolism by fluvoxamine.

MANAGEMENT: If these drugs must be used together, close observation for clinical and laboratory evidence of carbamazepine toxicity is recommended. A reduction of the carbamazepine dose may be required. Patients should be advised to report signs of carbamazepine toxicity (nausea, visual disturbances, dizziness, or ataxia) to their physician.

References
  • Spina E, Avenoso A, Pollicino AM, Caputi AP, Fazio A, Pisani F "Carbamazepine coadministration with fluoxetine or fluvoxamine." Ther Drug Monit 15 (1993): 247-50
  • "Product Information. Luvox (fluvoxamine)." Solvay Pharmaceuticals Inc, Marietta, GA.
  • Fritze J, Unsorg B, Lanczik M "Interaction between carbamazepine and fluvoxamine." Acta Psychiatr Scand 84 (1991): 583-4
  • Martinelli V, Bocchetta A, Palmas AM, Delzompo M "An interaction between carbamazepine and fluvoxamine." Br J Clin Pharmacol 36 (1993): 615-6
Fluvoxamine Tablets

Generic Name: fluvoxamine

Brand name: Luvox, Luvox CR

Synonyms: Fluvoxamine

Tegretol

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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