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Fluzone Intradermal Quadrivalent and Gilenya

Determining the interaction of Fluzone Intradermal Quadrivalent and Gilenya and the possibility of their joint administration.

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Fluzone Intradermal Quadrivalent <> Gilenya

Relevance: 20.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

If you are currently taking or have taken fingolimod within the past two months, you should talk to your doctor before receiving influenza virus vaccine, inactivated. Depending on the length of time you have been on fingolimod, you may have a reduced response to the vaccine. In some situations, your doctor may want to delay vaccination to give your body time to recover from the effects of fingolimod therapy. If you have recently been vaccinated with influenza virus vaccine, inactivated, your doctor may choose to postpone treatment with fingolimod for a couple of weeks to a month. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: The administration of inactivated, killed, or otherwise noninfectious vaccines during fingolimod therapy is generally safe but may be associated with a diminished or suboptimal immunologic response. Vaccination may be less effective during and for up to two months after discontinuation of fingolimod therapy. In healthy volunteers administered keyhole limpet Hemocyanin (KLH) and pneumococcal polysaccharide vaccine (PPV-23), antigen-specific IgM titers were decreased by 91% and 25% in response to KLH and PPV, respectively, in subjects receiving fingolimod 0.5 mg compared to placebo. Similarly, IgG titers were decreased by 45% and 50% in response to KLH and PPV, respectively, in subjects receiving fingolimod 0.5 mg compared to placebo. The responder rate for fingolimod 0.5 mg as measured by the number of subjects with a >4-fold increase in KLH IgG was comparable to placebo and 25% lower for PPV-23 IgG, while the number of subjects with a >4 fold increase in KLH and PPV-23 IgM was 75% and 40% lower, respectively, compared to placebo.

MANAGEMENT: Immune response to vaccines may be reduced during and for up to two months after discontinuation of fingolimod therapy. In patients who have recently been vaccinated, fingolimod therapy should preferably be postponed for one month to allow the full effect of vaccination to occur.

References

"Product Information. Gilenya (fingolimod)." Novartis Pharmaceuticals, East Hanover, NJ.

Fluzone Intradermal Quadrivalent

Generic Name: influenza virus vaccine, inactivated

Brand name: Afluria Quadrivalent, Afluria, Fluad, Fluarix Quadrivalent, Flucelvax Quadrivalent, FluShield, Fluzone SV, Fluzone WV, Fluzone PFS, Fluzone Preservative-Free Pediatric, Fluzone Preservative-Free, Fluvirin Preservative-Free, Afluria Preservative-Free, FluLaval 2010-2011, Afluria 2010-2011, Fluzone 2010-2011, Fluvirin 2010-2011, Afluria Preservative-Free 2010-2011, Fluzone Preservative-Free 2010-2011, Fluzone Preservative-Free Pediatric 2010-2011, Fluarix 2010-2011, Fluvirin Preservative-Free 2010-2011, Fluzone High-Dose 2010-2011, Fluzone 2011-2012, Fluzone Preservative-Free 2011-2012, Fluvirin Preservative-Free 2011-2012, Fluvirin 2011-2012, Afluria Preservative-Free 2011-2012, Afluria 2011-2012, Fluarix 2011-2012, Fluzone Preservative-Free Pediatric 2011-2012, Fluzone High-Dose 2011-2012, Fluzone Intradermal 2011-2012, FluLaval 2011-2012, Fluzone Preservative-Free Pediatric 2012-2013, Fluzone 2012-2013, Fluzone Preservative-Free 2012-2013, Fluvirin Preservative-Free 2012-2013, Fluvirin 2012-2013, Afluria Preservative-Free 2012-2013, Afluria 2012-2013, Agriflu 2012-2013, Fluarix 2012-2013, FluLaval 2012-2013, Fluzone High-Dose 2012-2013, Fluzone Intradermal 2012-2013, Flucelvax 2012-2013, FluLaval 2013-2014, Afluria 2013-2014, Afluria Preservative-Free 2013-2014, Fluzone 2013-2014, Fluzone Preservative-Free 2013-2014, Fluzone Preservative-Free Pediatric 2013-2014, Fluzone High-Dose 2013-2014, Fluzone Intradermal 2013-2014, Fluvirin 2013-2014, Fluvirin Preservative-Free 2013-2014, Flucelvax 2013-2014, Flublok 2012-2013, Fluzone Preservative-Free Quadrivalent 2013-2014, Fluzone Preservative-Free Pediatric Quadrivalent 2013-2014, Fluarix 2013-2014, Fluarix Quadrivalent 2013-2014, FluLaval Quadrivalent 2013-2014, Flublok 2013-2014, Fluzone 2014-2015, FluLaval 2014-2015, Fluvirin 2014-2015, Afluria 2014-2015, Fluzone Preservative-Free 2014-2015, Fluvirin Preservative-Free 2014-2015, Afluria Preservative-Free 2014-2015, Fluzone Preservative-Free Pediatric Quadrivalent 2014-2015, Fluzone Preservative-Free Quadrivalent 2014-2015, Fluarix Quadrivalent 2014-2015, FluLaval Quadrivalent 2014-2015, Flucelvax 2014-2015, Fluzone High-Dose 2014-2015, Fluzone Intradermal 2014-2015, Fluzone Quadrivalent 2014-2015, Flublok 2014-2015, FluLaval Preservative-Free Quadrival, Flublok, Flublok Quadrivalent, FluLaval

Synonyms: n.a.

What is Fluzone Intradermal Quadrivalent?

Gilenya

Generic Name: fingolimod

Brand name: Gilenya

Synonyms: n.a.

What is Gilenya?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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