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Fluzone Intradermal Quadrivalent and Zostavax

Determining the interaction of Fluzone Intradermal Quadrivalent and Zostavax and the possibility of their joint administration.

Check result:

Fluzone Intradermal Quadrivalent <> Zostavax

Relevance: 20.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

The safety and efficacy of concomitant administration of varicella-zoster virus (VZV) vaccine and trivalent inactivated influenza vaccine in adults aged 50 and older were demonstrated in a large randomized, controlled study conducted at 20 sites in the U.S. and Europe. The study compared 382 subjects who received the vaccines simultaneously at separate injection sites (vaccines on day one; placebo at week 4) to 380 subjects who received them sequentially (influenza vaccine and placebo on day one; VZV vaccine at week 4) and found no significant difference in antibody responses between the two groups. Four weeks postvaccination, VZV antibody geometric mean titers were 554 gpELISA units/mL for the concomitant group and 597 gpELISA units/mL for the sequential group. The estimated geometric mean titre ratios (concomitant/sequential) were 0.9 for influenza A (H1N1), 1.1 for influenza A (H3N2), and 0.9 for influenza B according to hemagglutination inhibition assay. Both concomitant and sequential administration were generally well tolerated, with a similar overall incidence of systemic adverse events of approximately 33% and vaccine-related systemic adverse events of approximately 5% within four weeks postvaccination.

References

Kerzner B, Murray AV, Cheng E, et al. "Safety and immunogenicity profile of the concomitant administration of ZOSTAVAX and inactivated influenza vaccine in adults aged 50 and older." J Am Geriatr Soc 55 (2007): 1499-507
"Product Information. Zostavax (zoster vaccine live)." Merck & Company Inc, West Point, PA.

Fluzone Intradermal Quadrivalent

Generic Name: influenza virus vaccine, inactivated

Brand name: Afluria Quadrivalent, Afluria, Fluad, Fluarix Quadrivalent, Flucelvax Quadrivalent, FluShield, Fluzone SV, Fluzone WV, Fluzone PFS, Fluzone Preservative-Free Pediatric, Fluzone Preservative-Free, Fluvirin Preservative-Free, Afluria Preservative-Free, FluLaval 2010-2011, Afluria 2010-2011, Fluzone 2010-2011, Fluvirin 2010-2011, Afluria Preservative-Free 2010-2011, Fluzone Preservative-Free 2010-2011, Fluzone Preservative-Free Pediatric 2010-2011, Fluarix 2010-2011, Fluvirin Preservative-Free 2010-2011, Fluzone High-Dose 2010-2011, Fluzone 2011-2012, Fluzone Preservative-Free 2011-2012, Fluvirin Preservative-Free 2011-2012, Fluvirin 2011-2012, Afluria Preservative-Free 2011-2012, Afluria 2011-2012, Fluarix 2011-2012, Fluzone Preservative-Free Pediatric 2011-2012, Fluzone High-Dose 2011-2012, Fluzone Intradermal 2011-2012, FluLaval 2011-2012, Fluzone Preservative-Free Pediatric 2012-2013, Fluzone 2012-2013, Fluzone Preservative-Free 2012-2013, Fluvirin Preservative-Free 2012-2013, Fluvirin 2012-2013, Afluria Preservative-Free 2012-2013, Afluria 2012-2013, Agriflu 2012-2013, Fluarix 2012-2013, FluLaval 2012-2013, Fluzone High-Dose 2012-2013, Fluzone Intradermal 2012-2013, Flucelvax 2012-2013, FluLaval 2013-2014, Afluria 2013-2014, Afluria Preservative-Free 2013-2014, Fluzone 2013-2014, Fluzone Preservative-Free 2013-2014, Fluzone Preservative-Free Pediatric 2013-2014, Fluzone High-Dose 2013-2014, Fluzone Intradermal 2013-2014, Fluvirin 2013-2014, Fluvirin Preservative-Free 2013-2014, Flucelvax 2013-2014, Flublok 2012-2013, Fluzone Preservative-Free Quadrivalent 2013-2014, Fluzone Preservative-Free Pediatric Quadrivalent 2013-2014, Fluarix 2013-2014, Fluarix Quadrivalent 2013-2014, FluLaval Quadrivalent 2013-2014, Flublok 2013-2014, Fluzone 2014-2015, FluLaval 2014-2015, Fluvirin 2014-2015, Afluria 2014-2015, Fluzone Preservative-Free 2014-2015, Fluvirin Preservative-Free 2014-2015, Afluria Preservative-Free 2014-2015, Fluzone Preservative-Free Pediatric Quadrivalent 2014-2015, Fluzone Preservative-Free Quadrivalent 2014-2015, Fluarix Quadrivalent 2014-2015, FluLaval Quadrivalent 2014-2015, Flucelvax 2014-2015, Fluzone High-Dose 2014-2015, Fluzone Intradermal 2014-2015, Fluzone Quadrivalent 2014-2015, Flublok 2014-2015, FluLaval Preservative-Free Quadrival, Flublok, Flublok Quadrivalent, FluLaval

Synonyms: n.a.

What is Fluzone Intradermal Quadrivalent?

Zostavax

Generic Name: zoster vaccine live

Brand name: Zostavax

Synonyms: n.a.

What is Zostavax?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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