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Fluzone Quadrivalent and Zevalin

Determining the interaction of Fluzone Quadrivalent and Zevalin and the possibility of their joint administration.

Check result:

Fluzone Quadrivalent <> Zevalin

Relevance: 08.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

If you are currently being treated or have recently been treated with ibritumomab tiuxetan, you should let your doctor know before receiving influenza virus vaccine, inactivated. Depending on the dose and length of time you have been on ibritumomab tiuxetan, you may have a reduced response to the vaccine. In some situations, your doctor may want to delay vaccination to give your body time to recover from the effects of ibritumomab tiuxetan therapy. If you have recently been vaccinated with influenza virus vaccine, inactivated, your doctor may choose to postpone treatment with ibritumomab tiuxetan for a couple of weeks. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: The administration of inactivated, killed, or otherwise noninfectious vaccines to immunosuppressed patients is generally safe but may be associated with a diminished or suboptimal immunologic response due to antibody inhibition. Such patients may include those who have recently received or are receiving immunosuppressive agents, antilymphocyte globulins, alkylating agents, antimetabolites, radiation, some antirheumatic agents, high dosages of corticosteroids or adrenocorticotropic agents (e.g., greater than 10 mg/day or 1 mg/kg/day of prednisone or equivalent for more than 2 weeks), or long-term topical or inhaled corticosteroids.

MANAGEMENT: In general, the US Department of Public Health Advisory Committee on Immunization Practices (ACIP) recommends that inactivated or killed vaccines be administered to non-HIV immunosuppressed patients according to the same guidelines as for healthy patients. However, higher dosages, more frequent boosters, and/or serological testing may be required in some cases. Local guidelines should be consulted. For Haemophilus influenzae b vaccine, some experts recommend that it be administered at least 2 weeks before starting or 3 months after discontinuing chemotherapy when used in patients with Hodgkin's disease. For rabies vaccine, some authorities agree that immunosuppressive agents should generally be avoided during postexposure therapy except when absolutely necessary for the treatment of other conditions. Vaccines may generally be administered to patients receiving corticosteroids as replacement therapy (e.g., for Addison's disease).

References

"Product Information. Imovax Rabies (rabies vaccine)." sanofi pasteur, Swiftwater, PA.
"Product Information. Omnihib (haemophilus b conjugate vaccine)." SmithKline Beecham, Philadelphia, PA.
Department of Health. National Health Service "Immunisation Against Infectious Disease - "The Green Book". Chapter 6: Contraindications and special considerations. Available from: URL: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/655225/Greenbook_chap" ([2017 Aug]):
Cerner Multum, Inc. "Australian Product Information." O 0
CDC. Centers for Disease Control and Prevention/ "Recommendations of the advisory committtee on immunization practices (ACIP): use of vaccines and immune globulins in persons with altered immunocompetence." MMWR Morb Mortal Wkly Rep 42(RR-04) (1993): 1-18
"Product Information. Havrix (hepatitis A vaccine)." SmithKline Beecham, Philadelphia, PA.
"Product Information. Biothrax (anthrax vaccine adsorbed)." Emergent BioSolutions Inc., Lansing, MI.
"Product Information. Influenza Virus Vaccine, H5N1, Inactivated (influenza virus vaccine, H5N1, inactivated)." GlaxoSmithKline, Research Triangle Park, NC.
"Product Information. Fluzone Influenza Vaccine (influenza virus vaccine)." Connaught, Swiftwater, PA.
CDC Centers for Disease Control and Prevention "General Best Practice Guidelines for Immunization: Altered Immunocompetence. Available from: URL: https://www.cdc.gov/vaccines/hcp/acip-recs/general-recs/immunocompetence.pdf." ([2017, Apr 17]):

Fluzone Quadrivalent

Generic Name: influenza virus vaccine, inactivated

Brand name: Afluria Quadrivalent, Afluria, Fluad, Fluarix Quadrivalent, Flucelvax Quadrivalent, FluShield, Fluzone SV, Fluzone WV, Fluzone PFS, Fluzone Preservative-Free Pediatric, Fluzone Preservative-Free, Fluvirin Preservative-Free, Afluria Preservative-Free, FluLaval 2010-2011, Afluria 2010-2011, Fluzone 2010-2011, Fluvirin 2010-2011, Afluria Preservative-Free 2010-2011, Fluzone Preservative-Free 2010-2011, Fluzone Preservative-Free Pediatric 2010-2011, Fluarix 2010-2011, Fluvirin Preservative-Free 2010-2011, Fluzone High-Dose 2010-2011, Fluzone 2011-2012, Fluzone Preservative-Free 2011-2012, Fluvirin Preservative-Free 2011-2012, Fluvirin 2011-2012, Afluria Preservative-Free 2011-2012, Afluria 2011-2012, Fluarix 2011-2012, Fluzone Preservative-Free Pediatric 2011-2012, Fluzone High-Dose 2011-2012, Fluzone Intradermal 2011-2012, FluLaval 2011-2012, Fluzone Preservative-Free Pediatric 2012-2013, Fluzone 2012-2013, Fluzone Preservative-Free 2012-2013, Fluvirin Preservative-Free 2012-2013, Fluvirin 2012-2013, Afluria Preservative-Free 2012-2013, Afluria 2012-2013, Agriflu 2012-2013, Fluarix 2012-2013, FluLaval 2012-2013, Fluzone High-Dose 2012-2013, Fluzone Intradermal 2012-2013, Flucelvax 2012-2013, FluLaval 2013-2014, Afluria 2013-2014, Afluria Preservative-Free 2013-2014, Fluzone 2013-2014, Fluzone Preservative-Free 2013-2014, Fluzone Preservative-Free Pediatric 2013-2014, Fluzone High-Dose 2013-2014, Fluzone Intradermal 2013-2014, Fluvirin 2013-2014, Fluvirin Preservative-Free 2013-2014, Flucelvax 2013-2014, Flublok 2012-2013, Fluzone Preservative-Free Quadrivalent 2013-2014, Fluzone Preservative-Free Pediatric Quadrivalent 2013-2014, Fluarix 2013-2014, Fluarix Quadrivalent 2013-2014, FluLaval Quadrivalent 2013-2014, Flublok 2013-2014, Fluzone 2014-2015, FluLaval 2014-2015, Fluvirin 2014-2015, Afluria 2014-2015, Fluzone Preservative-Free 2014-2015, Fluvirin Preservative-Free 2014-2015, Afluria Preservative-Free 2014-2015, Fluzone Preservative-Free Pediatric Quadrivalent 2014-2015, Fluzone Preservative-Free Quadrivalent 2014-2015, Fluarix Quadrivalent 2014-2015, FluLaval Quadrivalent 2014-2015, Flucelvax 2014-2015, Fluzone High-Dose 2014-2015, Fluzone Intradermal 2014-2015, Fluzone Quadrivalent 2014-2015, Flublok 2014-2015, FluLaval Preservative-Free Quadrival, Flublok, Flublok Quadrivalent, FluLaval

Synonyms: n.a.

What is Fluzone Quadrivalent?

Zevalin

Generic Name: ibritumomab

Brand name: Y-90 Zevalin, In-111 Zevalin

Synonyms: n.a.

What is Zevalin?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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