Folic Acid Capsules and Tablets and Rheumatrex
Determining the interaction of Folic Acid Capsules and Tablets and Rheumatrex and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Folic acid may reduce the effects of methotrexate. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration of methotrexate with vitamin preparations containing folic acid, folinic acid (leucovorin) or their derivatives may diminish the therapeutic effects of methotrexate. The proposed mechanism involves pharmacodynamic antagonism and/or competitive inhibition at the receptor site.
MANAGEMENT: Although folic acid or folinic acid are frequently used along with methotrexate to reduce adverse effects or as an antidote to high dose methotrexate therapy, patients receiving methotrexate should be advised to avoid the inadvertent use of vitamin preparations containing folic acid or its derivatives.
- "Product Information. Methotrexate Sodium (methotrexate)." Teva Pharmaceuticals (formerly IVAX), Miami, FL.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
Generic Name: folic acid
Brand name: FA-8, Folacin-800
Synonyms: Folic Acid
Generic Name: methotrexate
Brand name: Rheumatrex Dose Pack, Trexall, Xatmep, Otrexup, Rasuvo, Methotrexate Sodium, Preservative Free
Synonyms: Rheumatrex Dose Pack
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Folic Acid Capsules and Tablets-Rheumatrex Dose Pack
- Folic Acid Capsules and Tablets-Rheumatrex Dose Pack Oral
- Folic Acid Capsules and Tablets-Rhinall
- Folic Acid Capsules and Tablets-Rhinocort
- Folic Acid Capsules and Tablets-Rhinocort Allergy
- Folic Acid Capsules and Tablets-Rhinocort Aqua
- Rheumatrex-Folic Acid Injection
- Rheumatrex-Folic acid Oral, Injection
- Rheumatrex-Folic Acid, Cyanocobalamin, and Pyridoxine
- Rheumatrex-Folic Acid, Vitamin B6, Vitamin B12, Omega-3 Acids, and Phytosterols
- Rheumatrex-FoliTab 500
- Rheumatrex-Folivane-Plus