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Forane and Levophed

Determining the interaction of Forane and Levophed and the possibility of their joint administration.

Check result:

Forane <> Levophed

Relevance: 12.05.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using isoflurane together with norepinephrine. Taking these drugs together can affect the rhythm of your heart. Call your doctor if you have symptoms of irregular heartbeat, chest tightness, blurred vision, nausea, and seizures. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: The combination of norepinephrine and some anesthetics has resulted in ventricular irritability, serious cardiac arrhythmias, or death. The halogenated anesthetics sensitize the heart to the arrhythmogenic effects of catecholamines.

MANAGEMENT: This combination should be avoided or used very cautiously. If a halogenated anesthetic and norepinephrine must be used together, very low doses of norepinephrine concentrations are recommended and the patient's hemodynamic status should be closely monitored.

References

Cooke JE "Drug interactions in anesthesia." Clin Plast Surg 12 (1985): 83-9
"Product Information. Fluothane (halothane)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
Smith RB "Drug interactions and drug reactions." Otolaryngol Clin North Am 14 (1981): 615-29
Kainuma M, Suzuki A "Convulsions after adrenaline administration during enflurane anaesthesia." Anaesthesia 41 (1986): 874-5
Gold MI "Profound hypotension associated with preoperative use of phenothiazines." Anesth Analg 53 (1974): 844-8
Horrigan RW, Eger EI, Wilson C "Epinephrine-induced arrhythmias during enflurane anesthesia in man: a nonlinear dose-response relationship and dose-dependent protection from lidocaine." Anesth Analg 57 (1978): 547-50
Mostello L, Stueber K, Lake CR "Is topical application of epinephrine at skin graft donor sites during halothane anesthesia safe?" Ann Plast Surg 20 (1988): 313-6
Johnston RR, Eger EI II, Wilson C "A comparative interaction of epinephrine with enflurane, isoflurane, and halothane in man." Anesth Analg 55 (1976): 709-12
Reisner LS, Lippmann M "Ventricular arrhythmias after epinephrine injection in enflurane and in halothane anesthesia." Anesth Analg 54 (1975): 468-70
Cullen BF, Miller MG "Drug interactions and anesthesia: a review." Anesth Analg 58 (1979): 413-23
Pepple J "Epinephrine-halothane interaction in children versus adults." Anesthesiology 60 (1984): 76-8
Hirshom WI, Taylor RG, Sheehan JC "Arrhythmias produced by combinations of halothane and small amounts of vasopressor." Br J Oral Surg 2 (1964): 131-6
Bennett JA, Eltringham RJ "Possible dangers of anaesthesia in patients receiving fenfluramine. Results of animal studies following a case of human cardiac arrest." Anaesthesia 32 (1977): 8-13
Ueda W, Hirakawa M, Mae O "Appraisal of epinephrine administration to patients under halothane anesthesia for closure of cleft palate." Anesthesiology 58 (1983): 574-6
Konchigeri HN, Shaker MH, Winnie AP "Effect of epinephrine during enflurane anesthesia." Anesth Analg 53 (1974): 894-7
"Product Information. Ultane (sevoflurane)." Abbott Pharmaceutical, Abbott Park, IL.
Forbes AM "Halothane, adrenaline and cardiac arrest." Anaesthesia 21 (1966): 22-7
Snow JC, Shamsai J, Sakarya I "Effects of epinephrine during halothane anesthesia in mastoidotympanoplastic surgery." Anesth Analg 47 (1968): 252-6
Karl HW, Swedlow DB, Lee KW, Downes JJ "Epinephrine-halothane interactions in children." Anesthesiology 58 (1983): 142-5
Reisner LS, Lippmann M "Further data on epinephrine interactions." Anesth Analg 56 (1977): 468
Ghoneim MM "Drug interaction in anaesthesia. A review." Can Anaesth Soc J 18 (1971): 353-75

Forane

Generic Name: isoflurane

Brand name: Forane, Terrell

Synonyms: n.a.

What is Forane?

Levophed

Generic Name: norepinephrine

Brand name: Levophed, Levophed Bitartrate

Synonyms: n.a.

What is Levophed?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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