Fortovase and Fosamprenavir

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Coadministration of saquinavir with amprenavir or fosamprenavir may result in a reduction in the plasma concentrations and therapeutic effects of both drugs. The mechanism of the interaction has not been described. In 7 study subjects, saquinavir (800 mg three times a day for 2 weeks) decreased the peak plasma concentration (Cmax), area under the concentration-time curve (AUC) and trough plasma concentration (Cmin) of amprenavir (750 or 800 mg three times a day for 2 weeks) by 37%, 32%, and 14%, respectively, compared to administration of amprenavir alone. In another report, fosamprenavir (700 mg twice daily) decreased the AUC and Cmax of saquinavir (saquinavir-ritonavir 1000/100 mg twice daily) by 15% and 9%, respectively. The clinical significance of these changes is unknown. No dose adjustment is required for saquinavir-ritonavir. The need for a dosage adjustment for amprenavir or fosamprenavir has not been established.

Fortovase

Generic Name: saquinavir

Brand name: Invirase, Fortovase

Synonyms: n.a.

What is Fortovase?

Fosamprenavir

Generic Name: fosamprenavir

Brand name: Lexiva, Telzir

Synonyms: n.a.

What is Fosamprenavir?