Fortovase and Quin-G

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using saquinavir together with quiNIDine is not recommended. Saquinavir can increase the blood levels of quiNIDine to dangerous levels and cause an irregular heart rhythm that may be serious. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats during treatment with quiNIDine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Coadministration with saquinavir may significantly increase the plasma concentrations of some antiarrhythmic agents such as amiodarone, bepridil, flecainide, lidocaine, propafenone, and quinidine. The mechanism is decreased clearance due to inhibition of CYP450 3A4- and 2D6-mediated metabolism by saquinavir, particularly when coadministered with ritonavir as a pharmacokinetic booster. Although clinical data are lacking, the interaction could conceivably lead to serious and/or life-threatening reactions including QT interval prolongation and ventricular arrhythmias such as ventricular tachycardia and torsade de pointes.

MANAGEMENT: The use of saquinavir-ritonavir in combination with amiodarone, bepridil, flecainide, lidocaine, propafenone, and quinidine is considered contraindicated.

Fortovase

Generic Name: saquinavir

Brand name: Invirase, Fortovase

Synonyms: n.a.

What is Fortovase?

Quin-G

Generic Name: quinidine

Brand name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release

Synonyms: n.a.

What is Quin-G?