Fosaprepitant Injection and Seldane

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Terfenadine is no longer on the market in the US. Do not take terfenadine with any other medication.

CONTRAINDICATED: Coadministration with aprepitant or its prodrug, fosaprepitant, may increase the plasma concentrations of astemizole and terfenadine. The mechanism is inhibition of CYP450 3A4-mediated metabolism by aprepitant. High plasma levels of astemizole and terfenadine (e.g., due to overdose or interaction with other potent 3A4 inhibitors) have been associated with prolongation of the QT interval, which has led to cases of ventricular arrhythmias such as ventricular tachycardia and torsade de pointes as well as cardiac arrest and sudden death.

MANAGEMENT: Given the potential for serious and life-threatening adverse cardiac events associated with increased plasma levels of astemizole and terfenadine, concomitant use of aprepitant or fosaprepitant is considered contraindicated. Loratadine, cetirizine, or fexofenadine may be safer alternatives.

Fosaprepitant Injection

Generic Name: fosaprepitant

Brand name: Emend for Injection

Synonyms: Fosaprepitant

What is Fosaprepitant Injection?

Seldane

Generic Name: terfenadine

Brand name: Seldane

Synonyms: n.a.

What is Seldane?