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Foscarnet and Neoral

Determining the interaction of Foscarnet and Neoral and the possibility of their joint administration.

Check result:
Foscarnet <> Neoral
Relevance: 14.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using foscarnet together with cycloSPORINE. This can cause damage to the kidneys. Kidney function and drug levels in the blood may be monitored with blood tests during treatment. Talk with your doctor before using these medications together. You may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Renal failure risk may be increased in patients on foscarnet and cyclosporine therapy. The mechanism may be due to additive or synergistic nephrotoxicity. In two reported cases, cyclosporine concentrations remained within the therapeutic range and renal function returned to normal after discontinuation of the foscarnet.

MANAGEMENT: The manufacturer recommends avoiding the concurrent use of other nephrotoxic drugs during foscarnet therapy. If these agents are used concomitantly, consider close observation of renal function and discontinue foscarnet treatment if needed.

References
  • "Product Information. Foscavir (foscarnet)." Astra USA, Westborough, MA.
  • Morales JM, Munoz MA, Zatarain GF, et al. "Reversible acute renal failure caused by the combined use of foscarnet and cyclosporin in organ transplanted patients." Nephrol Dial Transplant 10 (1995): 882-3
Foscarnet

Generic Name: foscarnet

Brand name: Foscavir

Synonyms: n.a.

Neoral

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Neoral (Capsules, Modified)

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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Disease interaction