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Foscarnet Intravenous and Plazomicin Intravenous

Determining the interaction of Foscarnet Intravenous and Plazomicin Intravenous and the possibility of their joint administration.

Check result:

Foscarnet Intravenous <> Plazomicin Intravenous

Relevance: 01.10.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using foscarnet together with plazomicin can cause serious side effects to your kidneys. Using these drugs together can also increase your risks of seizures and an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. Call your doctor immediately if you experience nausea, swelling, sudden weight gain or weight loss, severe pain in your upper stomach spreading to your back, seizures, pounding heart beats, dizziness or chest pain. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: The potential nephrotoxicity of foscarnet and aminoglycosides may be additive. Concomitant use of these drugs could also lead to additive hypokalemia, hypomagnesemia, and hypocalcemia, which may increase the foscarnet-related risks of QT prolongation and seizures.

MANAGEMENT: The manufacturer recommends avoiding concomitant therapy unless the potential benefits outweigh the risks. Electrolyte levels and renal function of patients receiving these medications concomitantly should be monitored carefully, and dosages adjusted or discontinued if necessary.

References

Cacoub P, Deray G, Baumelou A, et al "Acute renal failure induced by foscarnet: 4 cases." Clin Nephrol 29 (1988): 315-8
"Product Information. Gentamicin Sulfate, Injectable (gentamicin)." Fresenius Kabi USA, LLC, Lake Zurich, IL.
SOCA Reseach Group, et al "Mortality in patients with the acquired immunodeficiency syndrome treated with either foscarnet or ganciclovir for cytomegalovirus retinitis." N Engl J Med 326 (1992): 213-20
Deray G, Martinez F, Katlama C, et al "Foscarnet nephrotoxicity: mechanism, incidence and prevention." Am J Nephrol 9 (1989): 316-21
Agencia Española de Medicamentos y Productos Sanitarios Healthcare "Centro de información online de medicamentos de la AEMPS - CIMA. Available from: URL: https://cima.aemps.es/cima/publico/home.html." ([2018]):
Jacobson MA "Review of the toxicities of foscarnet." J Acquir Immune Defic Syndr 5 (1992): s11-7
Blanshard C "Treatment of HIV-related cytomegalovirus disease of the gastrointestinal tract with foscarnet." J Acquir Immune Defic Syndr 5 (1992): s25-8
"Product Information. Arikayce (amikacin liposome)." Insmed Incorporated, Bridgewater, NJ.
Cerner Multum, Inc. "Canadian Product Information." O 0 (2015):
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Palestine AG, Polis MA, De Smet MD, et al "A randomized, controlled trial of foscarnet in the treatment of cytomegalovirus retinitis in patients with AIDS." Ann Intern Med 115 (1991): 665-73
Cotte L, Langlois M, Trepo C "Herpes simplex virus infection during foscarnet therapy." J Infect Dis 166 (1992): 447-8
"Product Information. Foscavir (foscarnet)." Astra USA, Westborough, MA.
Willocks L, Brettle R "Foscarnet and pancytopenia." J Antimicrob Chemother 29 (1992): 232
Ringden O, Lonnqvist B, Paulin T, et al "Pharmacokinetics, safety and preliminary clinical experiences using foscarnet in the treatment of cytomegalovirus infections in bone marrow and renal transplant recipients." J Antimicrob Chemother 17 (1986): 373-87
"Product Information. Amikin (amikacin)." Bristol-Myers Squibb, Princeton, NJ.
Cerner Multum, Inc "ANVISA Bulário Eletrônico. Available from: URL: http://www.anvisa.gov.br/datavisa/fila_bula/index.asp." O 0 (2015):
Farese RV Jr, Schambelan M, Hollander H, et al "Nephrogenic diabetes insipidus associated with foscarnet treatment of cytomegalovirus retinitis." Ann Intern Med 112 (1990): 955-6
Deray G, Katlama C, Dohin E "Prevention of foscarnet nephrotoxicity." Ann Intern Med 113 (1990): 332
Cerner Multum, Inc. "Australian Product Information." O 0
Deray G, Le Hoang P, Soubrie C, et al "Foscarnet-induced acute renal failure and effectiveness of haemodialysis." Lancet 2 (1987): 216

Foscarnet Intravenous

Generic Name: foscarnet

Brand name: Foscavir

Synonyms: Foscarnet

What is Foscarnet Intravenous?

Plazomicin Intravenous

Generic Name: plazomicin

Brand name: Zemdri

Synonyms: Plazomicin

What is Plazomicin Intravenous?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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