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Foscavir and Trizivir

Determining the interaction of Foscavir and Trizivir and the possibility of their joint administration.

Check result:
Foscavir <> Trizivir
Relevance: 09.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using zidovudine together with foscarnet can increase the blood levels or add to the side effects of either medication. Contact your doctor if you experience fever, chills, body aches, flu symptoms, nausea, vomiting, drowsiness, headache, weakness, pale skin, and easy bruising or bleeding. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: The potential bone marrow toxicity of foscarnet and zidovudine may be additive. Concomitant therapy may therefore increase the risk of anemia and other forms of myelosuppression.

MANAGEMENT: Patients should be closely monitored for evidence of hematologic effects (e.g., granulocytopenia, anemia, leukopenia, thrombocytopenia).

References
  • Palestine AG, Polis MA, De Smet MD, et al "A randomized, controlled trial of foscarnet in the treatment of cytomegalovirus retinitis in patients with AIDS." Ann Intern Med 115 (1991): 665-73
Foscavir

Generic Name: foscarnet

Brand name: Foscavir

Synonyms: n.a.

Trizivir

Generic Name: abacavir / lamivudine / zidovudine

Brand name: Trizivir

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction