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Fosfomycin and Reglan (Metoclopramide Injection Solution)

Determining the interaction of Fosfomycin and Reglan (Metoclopramide Injection Solution) and the possibility of their joint administration.

Check result:
Fosfomycin <> Reglan (Metoclopramide Injection Solution)
Relevance: 14.07.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Metoclopramide, when given concomitantly with fosfomycin, may lead to a lower serum concentration and urinary excretion of fosfomycin. The mechanism appears to be due to increased gastrointestinal mobility. There clinical significance is believed to be minor because urinary concentrations of fosfomycin remained adequate to control infection.

References
  • "Product Information. Monurol (fosfomycin)." Forest Pharmaceuticals, St. Louis, MO.
Fosfomycin

Generic Name: fosfomycin

Brand name: Monurol

Synonyms: n.a.

Reglan (Metoclopramide Injection Solution)

Generic Name: metoclopramide

Brand name: Reglan, Metozolv ODT

Synonyms: Reglan

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.