Fosphenytoin Injection and Oleptro
Determining the interaction of Fosphenytoin Injection and Oleptro and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using fosphenytoin together with traZODone may increase the fosphenytoin levels in your body. You may need dose adjustments or special tests in order to safely take both medications together. You should notify your doctor if you have symptoms such as drowsiness, visual problems, seizures, changes in behavior, nausea, or poor muscle coordination. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.
Professional:MONITOR: A case report has suggested that trazodone may increase serum phenytoin levels. Phenytoin toxicity has been reported. The mechanism of this interaction is unknown.
MANAGEMENT: If trazodone and a hydantoin must be used together, clinical monitoring of patient response, tolerance, and serum phenytoin concentrations is recommended. Patients should be advised to notify their physician if they experience symptoms of toxicity, including drowsiness, visual disturbances, change in mental status, seizures, nausea, or ataxia. The hydantoin dose may need to be decreased.
- Dorn JM "A case of phenytoin toxicity possibly precipitated by trazodone." J Clin Psychiatry 47 (1986): 89-90
Generic Name: fosphenytoin
Brand name: Cerebyx
Synonyms: Fosphenytoin
Generic Name: trazodone
Brand name: Oleptro, Desyrel, Desyrel Dividose
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Fosphenytoin Injection-Oleptro Oral
- Fosphenytoin Injection-Olmesartan
- Fosphenytoin Injection-Olmesartan and Hydrochlorothiazide
- Fosphenytoin Injection-Olmesartan Medoxomil
- Fosphenytoin Injection-Olmesartan Medoxomil and Hydrochlorothiazide
- Fosphenytoin Injection-Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide
- Oleptro-Fosphenytoin Sodium
- Oleptro-Fospropofol Intravenous
- Oleptro-Fosrenol
- Oleptro-Fosrenol (Lanthanum Chewable Tablets)
- Oleptro-Fosrenol (Lanthanum Powder)
- Oleptro-Fostamatinib