Fosphenytoin Injection and Quelicin
Determining the interaction of Fosphenytoin Injection and Quelicin and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using succinylcholine together with fosphenytoin may increase the effects of succinylcholine. Contact your doctor if you experience increased side effects or if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Chronic administration of anticonvulsants, including phenytoin and/or carbamazepine may prolong the effects of succinylcholine. The mechanism may be related to anticonvulsant-induced up-regulation of acetylcholine receptors.
MANAGEMENT: Close observation for reduced or prolonged succinylcholine effect is recommended if this drug must be used in a patient receiving chronic anticonvulsant therapy.
- Melton AT, Antognini JF, Gronert GA "Prolonged duration of succinylcholine in patients receiving anticonvulsants: evidence for mild up-regulation of acetylcholine receptors?" Can J Anaesth 40 (1993): 939-42
Generic Name: fosphenytoin
Brand name: Cerebyx
Synonyms: Fosphenytoin
Generic Name: succinylcholine
Brand name: Anectine, Quelicin
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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