Drug search by name

Fosphenytoin Injection and Silenor

Determining the interaction of Fosphenytoin Injection and Silenor and the possibility of their joint administration.

Check result:

Fosphenytoin Injection <> Silenor

Relevance: 15.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before taking doxepin, tell your doctor if you also use fosphenytoin. You may need dose adjustments or special tests in order to safely take both medications together. You should notify your doctor if you have loss of seizure control or symptoms such as drowsiness, visual disturbances, change in behavior, nausea, or loss of muscle coordination. An alternative antidepressant might be considered. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using your medications without first talking to your doctor.

Professional:

MONITOR: Tricyclic antidepressants may increase serum phenytoin levels. In vitro studies suggest the mechanism may involve inhibition of CYP450 2C19-catalyzed phenytoin p-hydroxylation by tricyclic antidepressants, especially imipramine and amitriptyline. Phenytoin may induce the hepatic metabolism of desipramine resulting in decreased plasma concentrations. In addition, tricyclic antidepressants may lower the seizure threshold.

MANAGEMENT: Clinical monitoring of patient response, tolerance, and serum phenytoin concentrations is recommended. Patients should be advised to notify their doctor if they experience loss of seizure control or symptoms of phenytoin toxicity (drowsiness, visual disturbances, change in mental status, nausea, or ataxia). Phenytoin dosage may need to be adjusted.

References

Cerner Multum, Inc "ANVISA Bulário Eletrônico. Available from: URL: http://www.anvisa.gov.br/datavisa/fila_bula/index.asp." O 0 (2015):
Cerner Multum, Inc. "Canadian Product Information." O 0 (2015):
Agencia Española de Medicamentos y Productos Sanitarios Healthcare "Centro de información online de medicamentos de la AEMPS - CIMA. Available from: URL: https://cima.aemps.es/cima/publico/home.html." ([2018]):
Houghton GW, Richens A "Inhibition of phenytoin metabolism by other drugs used in epilepsy." Int J Clin Pharmacol 12 (1975): 210-6
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0
Fogel BS, Haltzman S "Desipramine and phenytoin: a potential drug interaction of therapeutic relevance." J Clin Psychiatry 48 (1987): 387-8
Perucca E, Richens A "Interaction between phenytoin and imipramine." Br J Clin Pharmacol 4 (1977): 485-6
Shin JG, Park JY, Kim MJ, et al. "Inhibitory effects of tricyclic antidepressants (TCAs) on human cytochrome P450 enzymes in vitro: mechanism of drug interaction between TCAs and phenytoin." Drug Metab Dispos 30 (2002): 1102-7

Fosphenytoin Injection

Generic Name: fosphenytoin

Brand name: Cerebyx

Synonyms: Fosphenytoin

What is Fosphenytoin Injection?

Silenor

Generic Name: doxepin

Brand name: Silenor, Sinequan, Sinequan

Synonyms: n.a.

What is Silenor?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions