Fosphenytoin Injection and Trandolapril and verapamil
Determining the interaction of Fosphenytoin Injection and Trandolapril and verapamil and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using fosphenytoin together with verapamil may decrease the effects of verapamil. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Hydantoins may decrease verapamil serum concentrations and effectiveness. The mechanism is induction of CYP450 3A4 hepatic metabolism. Data are available for phenytoin only.
MANAGEMENT: Monitored for reduced efficacy of verapamil is recommended. The dosage should be increased as appropriate. Patients should be advised to notify their physician if they experience a worsening of their symptoms.
- Hedman A, Angelin B, Arvidsson A, et al "Digoxin-verapamil interaction: reduction of biliary but not renal digoxin clearance in humans." Clin Pharmacol Ther 49 (1991): 256-62
- Woodcock BG, Kirsten R, Nelson K, Rietbrock S, Hopf R, Kaltenbach M "A reduction in verapamil concentrations with phenytoin." N Engl J Med 325 (1991): 1179
Generic Name: fosphenytoin
Brand name: Cerebyx
Synonyms: Fosphenytoin
Generic Name: trandolapril / verapamil
Brand name: Tarka
Synonyms: Trandolapril and Verapamil
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Fosphenytoin Injection-Tranexamic acid
- Fosphenytoin Injection-Tranexamic Acid Injection
- Fosphenytoin Injection-Tranexamic acid Intravenous
- Fosphenytoin Injection-Tranexamic Acid Tablet
- Fosphenytoin Injection-Tranexamic Acid Tablets
- Fosphenytoin Injection-Tranquil
- Trandolapril and verapamil-Fosphenytoin Sodium
- Trandolapril and verapamil-Fospropofol Intravenous
- Trandolapril and verapamil-Fosrenol
- Trandolapril and verapamil-Fosrenol (Lanthanum Chewable Tablets)
- Trandolapril and verapamil-Fosrenol (Lanthanum Powder)
- Trandolapril and verapamil-Fostamatinib