Fosphenytoin Sodium and Gadobutrol Intravenous

• Generic Name: fosphenytoin
• Dosage Forms: n.a.
• Other Brand Names: Cerebyx

Treatment of generalized tonic-clonic status epilepticus.

Benzodiazepines (e.g., diazepam, lorazepam, midazolam) are considered drugs of choice for initial treatment of status epilepticus; IV fosphenytoin (or phenytoin) may be used as a second-line agent if seizures continue.

IV fosphenytoin appears to be better tolerated than IV phenytoin (e.g., fewer adverse cardiovascular effects), and some experts state that fosphenytoin is preferred when both agents are available.

Compared with IV phenytoin, IV fosphenytoin sodium is associated with fewer infusion site reactions (e.g., erythema, pain, burning, swelling, pruritus, soft tissue damage, phlebitis, necrosis) and less frequent need for infusion rate reduction, infusion interruption, and/or changes of infusion sites, but is associated with a higher incidence of systemic sensory disturbances (e.g., burning, paresthesia, pruritus).

Prevention and treatment of seizures occurring during neurosurgery.

May be used as a short-term parenteral replacement for oral phenytoin; because of risks associated with parenteral administration, manufacturer states fosphenytoin should only be used when oral phenytoin not possible.

• Generic Name: gadobutrol
• Dosage Forms: n.a.
• Other Brand Names: Gadavist

Gadobutrol injection is a magnetic resonance imaging (MRI) contrast agent that is used to help create a clear picture of the body during an MRI scan. MRI scans are a special kind of procedure that lets a doctor look at the inside of the body, such as the brain. They use magnets and computers to create images or “pictures” of the body. Unlike x-rays, MRI scans do not involve radiation. Gadobutrol is a gadolinium-based contrast agent (GBCA) that is given by injection before the MRI to help diagnose problems in the brain, spine, breast, and other parts of your body.

Gadobutrol injection is also used for magnetic resonance angiography (MRA) to evaluate known or suspected supra-aortic or renal artery disease in adults and children.

Gadobutrol is to be given only by or under the direct supervision of your doctor.