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Fosphenytoin Sodium and Neoral

Determining the interaction of Fosphenytoin Sodium and Neoral and the possibility of their joint administration.

Check result:

Fosphenytoin Sodium <> Neoral

Relevance: 26.02.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using fosphenytoin together with cycloSPORINE may decrease the effects of cycloSPORINE. Contact your doctor if your condition changes. If your doctor prescribes these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Phenytoin may significantly reduce cyclosporine serum concentrations. The mechanism may be inhibition of cyclosporine absorption or induction of hepatic CYP450 metabolism or both. This interaction may occur with ethotoin, fosphenytoin, and mephenytoin as well.

MANAGEMENT: Cyclosporine levels should be closely monitored during concomitant therapy and more frequently when phenytoin is started or stopped. The dosage of cyclosporine should be adjusted to maintain therapeutic concentrations. Some experts suggest that this interaction could persist for a week or more following discontinuation of phenytoin.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0
Freeman DJ, Laupacis A, Keown PA, et al "Evaluation of cyclosporin-phenytoin interaction with observations on cyclosporin metabolites." Br J Clin Pharmacol 18 (1984): 887-93
Keown PA, Laupacis A, Carruthers G, et al. "Interaction between phenytoin and cyclosporine following organ transplantation." Transplantation 38 (1984): 304-6
Rowland M, Gupta SK "Cyclosporin-phenytoin interaction: re-evaluation using metabolite data." Br J Clin Pharmacol 24 (1987): 329-34
Keown PA, Stiller CR, Laupacis AL, et al "The effects and side effects of cyclosporine: relationship to drug pharmacokinetics." Transplant Proc 14 (1982): 659-61
Schweitzer EJ, Canafax DM, Gillingham KJ, Najarian JS, Matas AJ "Phenytoin administration in kidney recipients on csa immunosuppression." J Am Soc Nephrol 2 (1991): 816
Schmidt H, Naumann R, Jaschonek K, Einsele H, Dopfer R, Ehninger G "Drug interaction between cyclosporin and phenytoin in allogeneic bone marrow transplantation." Bone Marrow Transplant 4 (1989): 212-3
"Product Information. Sandimmune (cyclosporine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
Yee GC, McGuire TR "Pharmacokinetic drug interactions with cyclosporin (Part I)." Clin Pharmacokinet 19 (1990): 319-32
Formea CM, Evans CG, Karlix JL "Altered cytochrome p450 metabolism of calcineurin inhibitors: case report and review of the literature." Pharmacotherapy 25 (2005): 1021-9

Fosphenytoin Sodium

Generic Name: fosphenytoin

Brand name: Cerebyx

Synonyms: Fosphenytoin

What is Fosphenytoin Sodium?

Neoral

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Neoral (Capsules, Modified)

What is Neoral?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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