Fosphenytoin Sodium and Rifadin IV Intravenous
Determining the interaction of Fosphenytoin Sodium and Rifadin IV Intravenous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using rifAMPin together with fosphenytoin may decrease the effects of fosphenytoin. Contact your doctor if your condition changes or if you experience loss of seizure control. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Rifampin and rifabutin may decrease plasma concentrations and effectiveness of hydantoins by inducing their CYP450 hepatic metabolism.
MANAGEMENT: Close observation for clinical and laboratory evidence of altered hydantoin effect is recommended. Patients should be advised to notify their physician if they experience loss of seizure control. Dosage should be increased as necessary.
- Kay L, Kampmann JP, Svedsen L, et al. "Influence of rifampicin and isoniazid on the kinetics of phenytoin." Br J Clin Pharmacol 20 (1985): 323-6
- Venkatesan K "Pharmacokinetic drug interactions with rifampicin." Clin Pharmacokinet 22 (1992): 47-65
- Abajo FJ "Phenytoin interaction with rifampicin." Br Med J 297 (1988): 1048
Generic Name: fosphenytoin
Brand name: Cerebyx
Synonyms: Fosphenytoin
Generic Name: rifampin
Brand name: Rifadin IV, Rifadin, Rimactane
Synonyms: Rifadin IV (Intravenous), Rifadin IV
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Fosphenytoin Sodium-Rifamate
- Fosphenytoin Sodium-Rifampin
- Fosphenytoin Sodium-Rifampin and Isoniazid
- Fosphenytoin Sodium-Rifampin Capsules
- Fosphenytoin Sodium-Rifampin Injection
- Fosphenytoin Sodium-Rifampin Intravenous
- Rifadin IV Intravenous-Fospropofol Intravenous
- Rifadin IV Intravenous-Fosrenol
- Rifadin IV Intravenous-Fosrenol (Lanthanum Chewable Tablets)
- Rifadin IV Intravenous-Fosrenol (Lanthanum Powder)
- Rifadin IV Intravenous-Fostamatinib
- Rifadin IV Intravenous-Fostamatinib disodium