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Fosteum and PCE Dispertab

Determining the interaction of Fosteum and PCE Dispertab and the possibility of their joint administration.

Check result:

Fosteum <> PCE Dispertab

Relevance: 01.03.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Antibiotics may decrease the effects of soy isoflavones such as genistein and daidzein. Soy isoflavones are converted into their active forms in part by intestinal bacteria, thus alteration of the intestinal microflora by antibiotics may decrease availability of activated isoflavones. Data are limited. In a study consisting of 11 children ages 4 to 17 years who were fed a body weight-adjusted dose of soy nuts, the urinary excretion rates for genistein and all native isoflavones combined (i.e., genistein, daidzein, and glycitein) were reduced by 37% and 24%, respectively, during oral antibiotic treatment for infection compared to the healthy state when not on antibiotics. The urinary excretion rate for total isoflavones (i.e., native and activated isoflavones combined) was also reduced by 24% during antibiotic administration. The clinical significance of these changes is unknown. There was some indication that the infectious process itself may have played a role, either by altering the colonic flora or some other mechanism, although the extent is unclear.

References

Therapeutic Research Faculty "Natural Medicines Comprehensive Database. Available from: URL: http://www.naturaldatabase.com." ([1995-2008...]):
Halm BM, Franke AA, Ashburn LA, Hebshi SM, Wilkens LR "Oral antibiotics decrease urinary isoflavonoid excretion in children after soy consumption." Nutr Cancer 60 (2008): 14-22

Fosteum

Generic Name: cholecalciferol / genistein / zinc glycinate

Brand name: Fosteum

Synonyms: n.a.

What is Fosteum?

PCE Dispertab

Generic Name: erythromycin

Brand name: EES. Granules, EES-400 Filmtab, EryPed 200, EryPed 400, Ery-Tab, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, PCE Dispertab, E. E. S, EryPed, Erythrocin, Erythromycin Filmtabs, Erythromycin Lactobionate - IV

Synonyms: PCE Dispertab (Oral), PCE, PCE (Oral)

What is PCE Dispertab?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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