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Furazolidone and Parnate

Determining the interaction of Furazolidone and Parnate and the possibility of their joint administration.

Check result:
Furazolidone <> Parnate
Relevance: 26.11.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using furazolidone together with tranylcypromine is not recommended. Combining these medications may lead to dangerous increases in your blood pressure, a condition known as hypertensive crisis. The risk of a stroke may also be increased. In general, it is necessary to wait at least a week between treatments with these medications. You should seek immediate medical attention if you experience sudden and severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness and/or fainting, as these may be signs and symptoms of a hypertensive crisis. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: The concomitant use of monoamine oxidase inhibitors (MAOIs) with other MAOIs may result in hypertensive crisis, convulsions, fever, delirium, coma, and circulatory collapse. Cases of hypertension with fatal and nonfatal stroke have been reported in patients who were switched from phenelzine or isocarboxazid to tranylcypromine. The mechanism is unknown.

MANAGEMENT: Administration of MAOIs with other MAOIs concurrently or in rapid succession is considered contraindicated. A washout period of at least 7 to 10 days is recommended when switching from one MAOI to another.

References
  • "Multum Information Services, Inc. Expert Review Panel"
  • Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  • Bazire SR "Sudden death associated with switching monoamine oxidase inhibitors." Drug Intell Clin Pharm 20 (1986): 954-6
Furazolidone

Generic Name: furazolidone

Brand name:

Synonyms: Furazolidone (Oral)

Parnate

Generic Name: tranylcypromine

Brand name: Parnate

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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