Furosemide and Hydralazine and isosorbide dinitrate
Determining the interaction of Furosemide and Hydralazine and isosorbide dinitrate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Hydralazine causes a significant increase in the plasma clearance of furosemide. A decrease in the elimination half-life of furosemide results. The mechanism is believed to be a hydralazine-induced increase in renal blood flow, which increases the plasma clearance (and diuretic effect) of furosemide. No special precautions appear to be necessary.
- Nomura A, Yasuda H, Katoh K, et al "Hydralazine and furosemide kinetics." Clin Pharmacol Ther 32 (1982): 303-6
Generic Name: furosemide
Brand name: Lasix, Diaqua-2, Lo-Aqua
Synonyms: n.a.
Generic Name: hydralazine / isosorbide dinitrate
Brand name: BiDil
Synonyms: Isosorbide Dinitrate and Hydralazine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Furosemide-Hydralazine Hydrochloride
- Furosemide-Hydralazine Injection
- Furosemide-Hydralazine Oral, Injection, Intravenous
- Furosemide-Hydralazine Tablets
- Furosemide-Hydrea
- Furosemide-Hydrisalic Topical
- Hydralazine and isosorbide dinitrate-Furosemide Injection
- Hydralazine and isosorbide dinitrate-Furosemide Oral Solution
- Hydralazine and isosorbide dinitrate-Furosemide Tablets
- Hydralazine and isosorbide dinitrate-FusePaq Fanatrex
- Hydralazine and isosorbide dinitrate-FusePaq Synapryn
- Hydralazine and isosorbide dinitrate-FusePaq Tabradol