Fusilev and Phenoxybenzamine Hydrochloride

• Generic Name: levoleucovorin
• Dosage Forms: injection, powder, lyophilized, for solution
• Other Brand Names: Fusilev, Khapzory

Fusilev is used to treat or prevent toxic effects of methotrexate in people who have received methotrexate to treat bone cancer.

Fusilev is also used to treat or prevent toxic effects of methotrexate in people whose bodies do not eliminate methotrexate properly after the drug is metabolized. This medicine may also be used to treat toxic effects of an overdose or methotrexate or certain other medications.

Fusilev is also used in combination chemotherapy with fluorouracil to treat colorectal cancer that has spread to other parts of the body. This medicine treats only the symptoms of colorectal cancer but does not treat the cancer itself.

Fusilev should not be used to treat anemia that is caused by a lack of vitamin B12.

Fusilev may also be used for purposes not listed in this medication guide.

• Generic Name: phenoxybenzamine
• Dosage Forms: n.a.
• Other Brand Names: Dibenzyline

Prevention or treatment of paroxysmal hypertension and sweating in patients with pheochromocytoma.

Considered drug of choice for medical management of pheochromocytoma until surgery is performed and for prolonged treatment of hypertension caused by pheochromocytoma notamenable to surgery.

Used in conjunction with a β-adrenergic blocking agent (propranolol) to control symptoms from excessive β-receptor stimulation in patients with inoperable or metastatic pheochromocytoma or to control tachycardia prior to or during pheochromocytomectomy. (See General under Dosage and Administration.)

Has been used as adjunctive therapy in the treatment of peripheral vasospastic disorders associated with increased α-adrenergic activity (e.g., Raynaud’s syndrome, acrocyanosis, and frostbite sequelae) but efficacy in the treatment of peripheral vascular disease is not established.

Phenoxybenzamine should not be used in diseases affecting large blood vessels.

Has been used in the treatment of micturition disorders resulting from neurogenic bladder, functional outlet obstruction, or partial prostatic obstruction.

Has been used for the prevention and treatment of acute postoperative urinary retention, including that associated with the use of epidural morphine.