Drug search by name

Gabarone and Mefloquine

Determining the interaction of Gabarone and Mefloquine and the possibility of their joint administration.

Check result:

Gabarone <> Mefloquine

Relevance: 10.03.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Mefloquine may increase the risk of seizures and decrease the effectiveness of gabapentin. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience a loss of seizure control or your condition changes during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Mefloquine may increase the risk of seizures and decrease the effectiveness of anticonvulsant drugs in patients with epilepsy. The mechanism is unknown, and it is unclear whether the seizures occur due to drug-drug or drug-disease interactions, as mefloquine alone and in combination with other related drugs (e.g., quinine, quinidine, chloroquine) have also been associated with seizures in some patients. It has been proposed that mefloquine may reduce the plasma levels of certain anticonvulsants such as sodium valproate, phenobarbital, carbamazepine, and phenytoin. Conversely, some anticonvulsants including carbamazepine, felbamate, phenytoin, phenobarbital, and primidone may also decrease the blood levels of mefloquine by inducing its metabolism via CYP450 3A4. The possibility of diminished therapeutic effects should be considered.

MANAGEMENT: Because it can increase the risk of seizures in patients with epilepsy, mefloquine should only be used for curative treatment of malaria in such patients and only if there are compelling medical reasons for its use. Patient clinical status and anticonvulsant blood levels should be closely monitored if mefloquine is prescribed. Dosage adjustments may be required. Patients should be advised to notify their doctor if they experience a loss of seizure control. Mefloquine should not be prescribed for malaria prophylaxis in patients with a history of convulsions.

References

Jimenez-Huete A, Gil-Nagel A, Franch O "Multifocal myoclonus associated with mefloquine chemoprophylaxis." Clin Neuropharmacol 25 (2002): 243
Pous E, Gascon J, Obach J, Corachan M "Mefloquine-induced grand mal seizure during malaria chemoprophylaxis in a non-epileptic subject." Trans R Soc Trop Med Hyg 89 (1995): 434
Singh K, Shanks GD, Wilde H "Seizures after mefloquine." Ann Intern Med 114 (1991): 994
Ries S, Pohlmanneden B "Seizures during malaria prophylaxis with mefloquine." Dtsch Med Wochenschr 118 (1993): 1911-2
Weinke T, Trautmann M, Held T, et al "Neuropsychiatric side effects after the use of mefloquine." Am J Trop Med Hyg 45 (1991): 86-91
"Product Information. Lariam (mefloquine)." Roche Laboratories, Nutley, NJ.
Bem JL, Kerr L, Stuerchler D "Mefloquine prophylaxis: an overview of spontaneous reports of severe psychiatric reactions and convulsions." J Trop Med Hyg 95 (1992): 167-79
Potasman I, Juven Y, Weller B, Schwartz E "Does mefloquine prophylaxis affect electroencephalographic patterns?" Am J Med 112 (2002): 147-9
Ruff TA, Sherwen SJ, Donnan GA "Seizure associated with mefloquine for malaria prophylaxis." Med J Aust 161 (1994): 453

Gabarone

Generic Name: gabapentin

Brand name: Gralise, Horizant, Neurontin, Gabarone

Synonyms: Gabarone (Oral)

What is Gabarone?

Mefloquine

Generic Name: mefloquine

Brand name: Lariam

Synonyms: n.a.

What is Mefloquine?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions