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Gadoxetate Intravenous and Timoptic-XE

Determining the interaction of Gadoxetate Intravenous and Timoptic-XE and the possibility of their joint administration.

Check result:

Gadoxetate Intravenous <> Timoptic-XE

Relevance: 28.12.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before you undergo any imaging procedure where gadoxetate may be given by injection, let your doctor know if you are currently being treated with timolol ophthalmic. Injection of gadoxetate can sometimes cause severe allergic reactions and low blood pressure, and the risk may be increased if you are also using timolol ophthalmic. In addition, treatment of the allergic reactions may be more difficult if medications like timolol ophthalmic are present in the body. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Limited data suggest that patients receiving beta-blockers may have an increased risk of severe hypotensive and/or hypersensitivity reactions to parenteral contrast media. In addition, allergic/anaphylactoid reactions in these patients may be more difficult to treat. The mechanism is unknown. Theoretically, beta-blocker ophthalmic solutions may also interact, as they are systemically absorbed and can produce clinically significant systemic effects even at low or undetectable plasma levels.

MANAGEMENT: Patients who have received beta-blockers should be closely monitored for adverse reactions to contrast media. If anaphylaxis occurs, clinicians should be aware that beta-blockers may attenuate the response to epinephrine. Thus, larger doses of epinephrine may be necessary to overcome the bronchospasm, although such large doses can also cause excessive alpha-adrenergic stimulation resulting in hypertension, reflex bradycardia, heart block, and possible potentiation of bronchospasm. Alternative treatments recommended include vigorous supportive care (e.g., fluids) and the use of parenteral beta-agonists for bronchospasm and norepinephrine for hypotension.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid."
Cerner Multum, Inc. "Australian Product Information." O 0
Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."

Gadoxetate Intravenous

Generic Name: gadoxetate disodium

Brand name: Eovist

Synonyms: Gadoxetate

What is Gadoxetate Intravenous?

Timoptic-XE

Generic Name: timolol ophthalmic

Brand name: Betimol, Istalol, Timoptic Ocudose, Timoptic Ocumeter, Timoptic Ocumeter Plus, Timoptic-XE, Timoptic

Synonyms: Timoptic XE

What is Timoptic-XE?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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