Galantamine Oral Solution and Kaletra

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ritonavir may increase the blood levels and effects of galantamine. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects such as nausea, vomiting, abdominal cramping, salivation, tearing, sweating, dizziness, lightheadedness, or fainting. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with potent inhibitors of CYP450 3A4 may increase the plasma concentrations of galantamine, which is partially metabolized by the isoenzyme. In multiple dose pharmacokinetic studies, a potent CYP450 3A4 inhibitor such as ketoconazole has been shown to increase galantamine systemic exposure (AUC) by 30%. Erythromycin and cimetidine, which are less potent inhibitors, have been shown to increase galantamine AUC by 10% and 16%, respectively.

MANAGEMENT: Pharmacologic response to galantamine should be monitored more closely whenever a potent CYP450 3A4 inhibitor (e.g., clarithromycin, telithromycin, itraconazole, ketoconazole, posaconazole, voriconazole, conivaptan, nefazodone, cobicistat, delavirdine, protease inhibitors) is added to or withdrawn from therapy, and the galantamine dosage adjusted as necessary. Patients should be advised to notify their physician if they experience excessive cholinergic symptoms such as severe nausea, vomiting, GI cramping, salivation, lacrimation, sweating, dizziness, or syncope.

Galantamine Oral Solution

Generic Name: galantamine

Brand name: Razadyne, Razadyne ER, Reminyl

Synonyms: Galantamine

What is Galantamine Oral Solution?

Kaletra

Generic Name: lopinavir / ritonavir

Brand name: Kaletra

Synonyms: n.a.

What is Kaletra?