Gantrisin Pediatric and Rheumatrex Dose Pack

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

SulfiSOXAZOLE may increase the blood levels of methotrexate. This may increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, mouth sores, ulcers, hair loss, liver and kidney problems, and impaired bone marrow function resulting in low numbers of different types of blood cells. You may also be more likely to develop anemia, bleeding problems, or infections due to low blood cell counts. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should contact your doctor if you develop paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Sulfonamide antibiotics may potentiate the toxicities of methotrexate, possibly by interfering with the plasma protein binding and/or renal clearance of methotrexate and its toxic metabolite. In a study of nine children with acute lymphoblastic leukemia given intravenous or oral methotrexate, a single dose of sulfamethoxazole-trimethoprim (SMX-TMP) increased the free fraction of methotrexate (MTX) from an average of 37.4% to 52.2%. In addition, plasma clearance and renal clearance of free MTX decreased by nearly 40% and 54%, respectively, in the presence of SMX-TMP. These changes were determined to increase systemic exposure to MTX by an average of 66%. On the contrary, two other studies found no significant effect of SMX-TMP on the pharmacokinetics of MTX. The interaction has not been studied with other sulfonamide antibiotics. Because changes in renal function can sometimes occur during sulfonamide therapy, reduced MTX clearance is a possibility regardless of whether or not a pharmacokinetic interaction has been demonstrated.

MANAGEMENT: Caution is advised when methotrexate is used with sulfonamides. Complete blood counts, liver enzymes, and serum creatinine levels should be performed at baseline and periodically during treatment. Patients should be closely monitored for increased methotrexate adverse effects including nausea, vomiting, diarrhea, stomatitis, alopecia, anemia, bone marrow suppression (e.g., aplastic anemia, leukopenia, neutropenia, thrombocytopenia., pancytopenia), hepatotoxicity, and nephrotoxicity.

Gantrisin Pediatric

Generic Name: sulfisoxazole

Brand name:

Synonyms: Gantrisin Pediatric (Oral)

What is Gantrisin Pediatric?

Rheumatrex Dose Pack

Generic Name: methotrexate

Brand name: Rheumatrex Dose Pack, Trexall, Xatmep, Otrexup, Rasuvo, Methotrexate Sodium, Preservative Free

Synonyms: Rheumatrex

What is Rheumatrex Dose Pack?