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Garlic and Tolazamide

Determining the interaction of Garlic and Tolazamide and the possibility of their joint administration.

Check result:
Garlic <> Tolazamide
Relevance: 14.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Some authors suggest that garlic may potentiate the hypoglycemic effect of insulin and oral antidiabetic agents, although supportive evidence is scarce. While garlic has been used in the treatment of diabetes, data from small, randomized trials in individuals with and without diabetes have not demonstrated clinically significant effects on blood glucose or insulin sensitivity. There has been a case report describing a potential interaction between chlorpropamide and a curry containing garlic and karela to which the author attributed primarily to the latter ingredient.

References
  • Izzo AA, Ernst E "Interactions between herbal medicines and prescribed drugs: a systematic review." Drugs 61 (2001): 2163-75
  • Semaan N "Integration of complementary disciplines into the oncology clinic - Part III. Herbal medicine - Drug interactions: The role of the pharmacist." Curr Prob Cancer 24 (2000): 213-22
  • Mulrow C, Lawrence V, Ackermann R, et al. Agency for Healthcare Research and Quality "Garlic: effects on cardiovascular risks and disease, protective effects against cancer, and clinical adverse effects. Evidence Report/Technology Assessment Number 20. AHRQ Publication No. 01-E023 Available from: URL: http://www.ahrq.gov/clinics/garlicsum." ([2000 Oct]):
  • Aslam M, Stockley IH "Interaction between curry ingredient (karela) and drug (chlorpropamide)." Lancet I (1979): 607
Garlic

Generic Name: garlic

Brand name: Garlic Oil

Synonyms: n.a.

Tolazamide

Generic Name: tolazamide

Brand name: Tolinase

Synonyms: TOLAZamide

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction