Gatifloxacin and prednisolone ophthalmic and Nifedical XL
Determining the interaction of Gatifloxacin and prednisolone ophthalmic and Nifedical XL and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:The plasma concentration of some calcium channel blockers may be increased by H2 blockers such as cimetidine and ranitidine. The mechanism is related to inhibition of liver cytochrome P450 enzymes responsible for metabolism and/or increased gastric pH. Ranitidine is a much weaker inhibitor of the cytochrome P450 system and effects are not expected to be clinically significant. Other H2 blockers, antacids, and proton pump inhibitors that notably increase gastric pH would be expected to have a similar effect. Clinical monitoring of patient response and tolerance is recommended and calcium channel blocker dosage adjustments may be indicated.
- "Product Information. Tagamet (cimetidine)." SmithKline Beecham, Philadelphia, PA.
- "Product Information. Zantac (ranitidine)." Glaxo Wellcome, Research Triangle Park, NC.
Generic Name: gatifloxacin / prednisolone ophthalmic
Brand name: Baciguent, Probiotic Formula, Proferrin-ES
Synonyms: n.a.
Generic Name: nifedipine
Brand name: Adalat CC, Afeditab CR, Nifediac CC, Nifedical XL, Procardia, Procardia XL, Adalat
Synonyms: Nifedical XL (Oral)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Gatifloxacin and prednisolone ophthalmic-Nifedipine
- Gatifloxacin and prednisolone ophthalmic-Nifedipine Capsules
- Gatifloxacin and prednisolone ophthalmic-Nifedipine Extended-Release Tablets
- Gatifloxacin and prednisolone ophthalmic-Niferex
- Gatifloxacin and prednisolone ophthalmic-Niferex Elixir
- Gatifloxacin and prednisolone ophthalmic-Night Cast R Topical
- Nifedical XL-Gattex
- Nifedical XL-Gattex Injection
- Nifedical XL-GaviLAX
- Nifedical XL-GaviLyte-C
- Nifedical XL-GaviLyte-C with Flavor Pack
- Nifedical XL-GaviLyte-G