Gaviscon Tablet and Gengraf Capsules

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using aluminum hydroxide together with cycloSPORINE may decrease the effects of cycloSPORINE. CycloSPORINE should be administered at least two hours before or six hours after aluminum hydroxide. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSING INTERVAL: The blood concentrations of orally administered cyclosporine were reported to have decreased rapidly in a pediatric patient who had been administered cyclosporine combined with dried aluminum hydroxide gel. One study (n=46) concluded that the blood concentrations of cyclosporine were affected by coadministration with dried aluminum hydroxide gel. The proposed mechanism of this interaction is adsorption or complex formation by aluminum. Other aluminum salts may interact in a similar manner.

MANAGEMENT: Oral cyclosporine should be administered 2 hours before or 6 hours after the aluminum salt in order to avoid this potential interaction. The patient's therapeutic response should be monitored.

Gaviscon Tablet

Generic Name: aluminum hydroxide / magnesium trisilicate

Brand name: Gaviscon Tablet, Drysol, Hypercare, Xerac AC

Synonyms: Aluminum Hydroxide and Magnesium Trisilicate

What is Gaviscon Tablet?

Gengraf Capsules

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Gengraf (Capsules, Modified), Gengraf

What is Gengraf Capsules?