Gefitinib Oral and Proferrin-ES

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using gefitinib together with raNITIdine. RaNITIdine can interfere with the absorption of gefitinib and reduce its effectiveness. Combining these medications is generally not recommended. Your doctor or pharmacist may be able to offer suggestions on alternatives to treat stomach acid or ulcer, such as certain antacids. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with drugs that cause significant, sustained elevations in gastric pH such as H2-receptor antagonists and proton pump inhibitors may decrease the plasma concentrations of gefitinib. The exact mechanism of interaction is unknown. According to the manufacturer, coadministration with high dosages of ranitidine and sodium bicarbonate (to maintain the gastric pH above 5.0) reduced the mean area under the plasma concentration-time curve of gefitinib by 44% in healthy male volunteers.

MANAGEMENT: The possibility of a diminished therapeutic response to gefitinib should be considered during coadministration with H2-receptor antagonists or proton pump inhibitors. Pharmacologic response to gefitinib should be monitored more closely whenever one of these agents is added to or withdrawn from therapy.

Gefitinib Oral

Generic Name: gefitinib

Brand name: Iressa

Synonyms: Gefitinib

What is Gefitinib Oral?

Proferrin-ES

Generic Name: heme iron polypeptide

Brand name: Proferrin-ES, Baciguent, Probiotic Formula

Synonyms: n.a.

What is Proferrin-ES?