Gefitinib Oral and Viramune XR
Determining the interaction of Gefitinib Oral and Viramune XR and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Nevirapine may reduce the blood levels and effects of gefitinib. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSE: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of gefitinib, which is primarily metabolized by the isoenzyme. According to the manufacturer, rifampin reduced the mean area under the plasma concentration-time curve of gefitinib by 85% in healthy male volunteers.
MANAGEMENT: Pharmacologic response to gefitinib should be monitored more closely whenever a CYP450 3A4 inducer is added to or withdrawn from therapy. In patients receiving potent inducers such as rifampin or phenytoin, gefitinib product labeling states that a dosage increase to 500 mg daily should be considered in the absence of severe adverse reactions, and additional dosage adjustments be made based on clinical response. Gefitinib dosage should be decreased accordingly if these agents are discontinued.
- Li J, Zhao M, He P, Hidalgo M, Baker SD "Differential metabolism of gefitinib and erlotinib by human cytochrome p450 enzymes." Clin Cancer Res 13 (2007): 3731-7
- "Product Information. Iressa (gefitinib)." Astra-Zeneca Pharmaceuticals, Wilmington, DE.
Generic Name: gefitinib
Brand name: Iressa
Synonyms: Gefitinib
Generic Name: nevirapine
Brand name: Viramune, Viramune XR
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Gefitinib Oral-Virasal
- Gefitinib Oral-Virasal Topical
- Gefitinib Oral-Viravan P
- Gefitinib Oral-Viravan PDM
- Gefitinib Oral-Virazole
- Gefitinib Oral-Viread
- Viramune XR-Gel-One
- Viramune XR-Gel-One injection
- Viramune XR-Gelato Topical Anesthetic
- Viramune XR-Gelato Topical Anesthetic Gel
- Viramune XR-Gelnique
- Viramune XR-Gelsyn-3 injection