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Gemcitabine Hydrochloride and Taxol

Determining the interaction of Gemcitabine Hydrochloride and Taxol and the possibility of their joint administration.

Check result:

Gemcitabine Hydrochloride <> Taxol

Relevance: 08.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using PACLitaxel together with gemcitabine may decrease the effects of gemcitabine. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with paclitaxel may increase the plasma concentrations of gemcitabine, and high levels of gemcitabine may inhibit the intracellular accumulation of its active triphosphate metabolite. The mechanism of interaction has not been described. In one study, 14 patients with advanced non-small cell lung cancer received paclitaxel (110 mg/m2 over 3 hours) followed by gemcitabine (800 mg/m2 over 80 minutes) on days 1 and 8 every 21 days, with the exception of day 1 of cycle 1 when they received gemcitabine alone. Of 13 patients included in the pharmacokinetic analysis, 61% achieved the desired steady-state gemcitabine plasma concentration (10 to 20 microM) when the drug was administered alone, compared to 0% to 45% during cycles with paclitaxel. Paclitaxel significantly decreased systemic clearance and volume of distribution of gemcitabine, resulting in increased steady-state concentration. Gemcitabine pharmacokinetics demonstrated great interpatient variability when given alone, which was not observed during coadministration with paclitaxel.

MANAGEMENT: The potential for diminished pharmacologic effects of gemcitabine should be considered during coadministration with paclitaxel.

References

Shord SS, Faucette SR, Gillenwater HH, et al. "Gemcitabine pharmacokinetics and interaction with paclitaxel in patients with advanced non-small-cell lung cancer." Cancer Chemother Pharmacol 51 (2003): 328-336

Gemcitabine Hydrochloride

Generic Name: gemcitabine

Brand name: Gemzar, Infugem

Synonyms: Gemcitabine

What is Gemcitabine Hydrochloride?

Taxol

Generic Name: paclitaxel

Brand name: Onxol, Taxol

Synonyms: n.a.

What is Taxol?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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