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Gemfibrozil and Questran

Determining the interaction of Gemfibrozil and Questran and the possibility of their joint administration.

Check result:

Gemfibrozil <> Questran

Relevance: 21.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Taking the gemfibrozil and cholestyramine doses too close together may interfere with the absorption of gemfibrozil and reduce its effectiveness. To prevent or minimize the interaction, gemfibrozil and cholestyramine dosing should be separated by at least two hours. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: Bile acid sequestrants may bind to and decrease the gastrointestinal absorption of gemfibrozil.

MANAGEMENT: Gemfibrozil and bile acid sequestrants should be taken at least 2 hours apart.

References

Cerner Multum, Inc. "Australian Product Information." O 0
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Forland SC, Feng Y, Cutler RE "Apparent reduced absorption of gemfibrozil when given with colestipol." J Clin Pharmacol 30 (1990): 29-32
Lozada A, Dujovne CA "Drug interactions with fibric acids." Pharmacol Ther 63 (1994): 163-76
Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."

Gemfibrozil

Generic Name: gemfibrozil

Brand name: Lopid

Synonyms: n.a.

What is Gemfibrozil?

Questran

Generic Name: cholestyramine

Brand name: Cholestyramine Light, Prevalite, Questran, Questran Light, Locholest, Locholest Light, Questran Light Packets, Prevalite Packets, Questran Packets

Synonyms: n.a.

What is Questran?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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