Gemfibrozil and Selexipag

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using selexipag together with gemfibrozil is not recommended. Combining these drugs can increase the blood levels of selexipag and this may increase side effects such as anemia, muscle and joint pain, diarrhea, nausea, vomiting, flushing and decreased appetite. Talk to your doctor if you have any questions or concerns. Your doctor may prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Coadministration with potent inhibitors of CYP450 2C8 may significantly increase the plasma concentrations of selexipag and its active metabolite. In 20 healthy male subjects, treatment with the potent CYP450 2C8 inhibitor gemfibrozil (600 mg twice a day on days 1 to 9) in combination with selexipag (400 mcg once in the morning on day 4) resulted in a 1.4 and 2-fold increase in the Cmax and AUC of selexipag, respectively, and a 3.6 and 11.1-fold increase in the Cmax and AUC of its active metabolite, respectively.

MANAGEMENT: Concomitant use of selexipag with potent CYP450 2C8 inhibitors is contraindicated by the manufacturer.

Gemfibrozil

Generic Name: gemfibrozil

Brand name: Lopid

Synonyms: n.a.

What is Gemfibrozil?

Selexipag

Generic Name: selexipag

Brand name: Uptravi, Uptravi Titration Pack

Synonyms: n.a.

What is Selexipag?