Gemzar and Necitumumab

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Coadministration with necitumumab may increase the plasma concentrations of gemcitabine. The mechanism of interaction has not been described. In 12 study patients with advanced solid tumors who received gemcitabine and cisplatin with necitumumab, dose-normalized mean gemcitabine peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 63% and 22%, respectively, compared to administration of gemcitabine and cisplatin alone. Mean AUCs of cisplatin and necitumumab were unchanged.

Gemzar

Generic Name: gemcitabine

Brand name: Gemzar, Infugem

Synonyms: n.a.

What is Gemzar?

Necitumumab

Generic Name: necitumumab

Brand name: Portrazza

Synonyms: n.a.

What is Necitumumab?