Generess FE and Imatinib Mesylate
Determining the interaction of Generess FE and Imatinib Mesylate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Imatinib may increase the blood levels and effects of ethinyl estradiol. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with imatinib may increase the plasma concentrations of drugs that are substrates of CYP450 2C9, 2D6 and/or 3A4. The mechanism is decreased clearance due to inhibition of these isoenzymes by imatinib. According to the manufacturer, imatinib increased the mean peak plasma concentration (Cmax) and systemic exposure (AUC) of simvastatin, a sensitive CYP450 3A4 substrate, by 2- and 3.5-fold, respectively. Data for other substrates are limited, although human liver microsome studies indicate that imatinib is a potent competitive inhibitor of all three isoenzymes.
MANAGEMENT: Caution is advised when imatinib is used concomitantly with drugs that undergo metabolism by CYP450 2C9, 2D6 and/or 3A4, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever imatinib is added to or withdrawn from therapy.
- "Product Information. Gleevec (imatinib mesylate)." Novartis Pharmaceuticals, East Hanover, NJ.
Generic Name: ethinyl estradiol / norethindrone
Brand name: Femcon Fe, Generess FE, Blisovi 24 Fe, Estrostep Fe, Femcon Fe, Kaitlib FE, Lo Minastrin Fe, Microgestin 24 Fe, Norinyl 1+35, Ortho-Novum 7/7/7, Taytulla, Tri-Norinyl, Zenchent, Blisovi 24 Fe, Blisovi Fe 15/30, Blisovi Fe 1/20, Gildess 24 Fe, Gildess Fe 15/30, Gildess Fe 1/20, Junel Fe 15/30, Junel Fe 1/20, Junel Fe 24, Larin 24 Fe, Larin Fe 15/30, Larin Fe 1/20, Lo Loestrin Fe, Loestrin 24 Fe, Loestrin Fe 15/30, Loestrin Fe 1/20, Lomedia 24 Fe, Microgestin 24 Fe, Microgestin Fe 15/30, Microgestin Fe 1/20, Tarina Fe 1/20, Tilia Fe, Tri-Legest Fe, femhrt 05 mg/25 mcg, Fyavolv, Jevantique Lo, Jinteli, Loestrin 1/20, Ovcon 35, Brevicon
Synonyms: Generess Fe
Generic Name: imatinib
Brand name: Gleevec
Synonyms: Imatinib
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Generess FE-Imbruvica
- Generess FE-Imbruvica (Ibrutinib Capsules)
- Generess FE-Imbruvica (Ibrutinib Tablets)
- Generess FE-Imdur
- Generess FE-Imdur ER
- Generess FE-Imfinzi
- Imatinib Mesylate-Generlac
- Imatinib Mesylate-Geneye Extra
- Imatinib Mesylate-Geneyes
- Imatinib Mesylate-Gengraf
- Imatinib Mesylate-Gengraf (Cyclosporine Capsules, Modified)
- Imatinib Mesylate-Gengraf (Cyclosporine Oral Solution, Modified)