About us Contacts Drug interactions: 390 212
Drug search by name

Generlac and Neomycin Oral Solution

Determining the interaction of Generlac and Neomycin Oral Solution and the possibility of their joint administration.

Check result:
Generlac <> Neomycin Oral Solution
Relevance: 01.05.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

On theoretical grounds and based on limited experimental data in rats, coadministration with neomycin may presumably reduce the effectiveness of lactulose in the treatment of portal-systemic encephalopathy by eliminating certain colonic bacteria necessary for the degradation of lactulose to organic acids. However, the relevance of this interaction has not been fully elucidated. Clinical data do not appear to support a significant effect of neomycin on lactulose-induced reduction of colonic pH, and concomitant use has resulted in positive effects on various therapeutic markers of portal-systemic encephalopathy.

References
  • "Product Information. Chronulac (lactulose)." Hoechst Marion-Roussel Inc, Kansas City, MO.
  • "Product Information. Cephulac (lactulose)." Hoechst Marion-Roussel Inc, Kansas City, MO.
  • "Product Information. Enulose (lactulose)." United Research Laboratories/Mutual Pharmaceutical Company, Philadelphia, PA.
  • Conn HO "Interactions of lactulose and neomycin." Drugs 4 (1972): 4-6
Generlac

Generic Name: lactulose

Brand name: Enulose, Generlac, Constulose, Kristalose, Duphalac, Chronulac, Cephulac, Constilac, Cholac, Evalose, Heptalac

Synonyms: n.a.

Neomycin Oral Solution

Generic Name: neomycin

Brand name: Neo-Fradin, Neo-Tab, Mycifradin

Synonyms: Neomycin

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction