Gengraf and Probucol
Determining the interaction of Gengraf and Probucol and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using probucol together with cycloSPORINE may decrease the effects of cycloSPORINE. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: The concomitant administration of probucol may modestly decrease oral cyclosporine concentrations. The mechanism is unknown. Subtherapeutic cyclosporine levels may increase the risk of rejection in transplant patients.
MANAGEMENT: Monitoring for altered efficacy and cyclosporine blood concentrations is recommended during concurrent therapy. Dose adjustments may be required if an interaction is suspected.
- "Product Information. Neoral Soft Gelatin Capsules (cyclosporine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
- Sundararajan V, Cooper DK, Muchmore J, et al "Interaction of cyclosporine and probucol in heart transplant patients." Transplant Proc 23 (1991): 2028-32
Generic Name: cyclosporine
Brand name: Gengraf, Neoral, Sandimmune, Sandimmune
Synonyms: Gengraf (Capsules, Modified)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Gengraf-Probuphine
- Gengraf-Procainamide
- Gengraf-Procainamide capsules
- Gengraf-Procainamide Hydrochloride
- Gengraf-Procainamide injection
- Gengraf-Procainamide Intravenous
- Probucol-Gengraf (Cyclosporine Capsules, Modified)
- Probucol-Gengraf (Cyclosporine Oral Solution, Modified)
- Probucol-Gengraf Capsules
- Probucol-Gengraf Oral
- Probucol-Gengraf Oral Solution
- Probucol-Genicin