Gengraf and Rubraca
Determining the interaction of Gengraf and Rubraca and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:CycloSPORINE may increase the blood levels and effects of rucaparib. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with potent inhibitors of P-glycoprotein (P-gp) may increase the plasma concentration and the risk of adverse effects of rucaparib, which has been shown to be a substrate of P-gp. However, the effects on the pharmacokinetics of rucaparib have not been evaluated in vivo.
MANAGEMENT: Caution is advised if rucaparib is used concomitantly with potent P-gp inhibitors. Dosage adjustments as well as clinical and laboratory monitoring should be considered whenever a potent P-gp inhibitor is added to or withdrawn from therapy with rucaparib.
- EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/regulation/document_listing/document_listing_000366.jsp&mid=WC0b01ac058067c852" ([2013 - ]):
Generic Name: cyclosporine
Brand name: Gengraf, Neoral, Sandimmune, Sandimmune
Synonyms: Gengraf (Capsules, Modified)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Gengraf-Rubramin PC
- Gengraf-Rucaparib
- Gengraf-Rucaparib Camsylate
- Gengraf-Ruconest
- Gengraf-Rufinamide
- Gengraf-Rufinamide Oral Suspension
- Rubraca-Gengraf (Cyclosporine Capsules, Modified)
- Rubraca-Gengraf (Cyclosporine Oral Solution, Modified)
- Rubraca-Gengraf Capsules
- Rubraca-Gengraf Oral
- Rubraca-Gengraf Oral Solution
- Rubraca-Genicin