Gengraf and Tibsovo
Determining the interaction of Gengraf and Tibsovo and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.GENERALLY AVOID: Coadministration with ivosidenib may decrease the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. No pharmacokinetic data are available; however, ivosidenib induces its own metabolism via CYP450 3A4. MANAGEMENT: Concomitant use of ivosidenib and sensitive CYP450 3A4 substrates or substrates with narrow therapeutic ranges should generally be avoided. If coadministration is required, patients should be monitored carefully for potential loss of therapeutic effects. References "Product Information. Tibsovo (ivosidenib)." Agios Pharmaceuticals, Cambridge, MA.
Professional:GENERALLY AVOID: Coadministration with ivosidenib may decrease the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. No pharmacokinetic data are available; however, ivosidenib induces its own metabolism via CYP450 3A4.
MANAGEMENT: Concomitant use of ivosidenib and sensitive CYP450 3A4 substrates or substrates with narrow therapeutic ranges should generally be avoided. If coadministration is required, patients should be monitored carefully for potential loss of therapeutic effects.
- "Product Information. Tibsovo (ivosidenib)." Agios Pharmaceuticals, Cambridge, MA.
Generic Name: cyclosporine
Brand name: Gengraf, Neoral, Sandimmune, Sandimmune
Synonyms: Gengraf (Capsules, Modified)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Gengraf-Ticagrelor
- Gengraf-Ticalast
- Gengraf-Ticanase
- Gengraf-Ticar
- Gengraf-Ticarcillin and clavulanate Intravenous
- Gengraf-Ticarcillin and Clavulanate Potassium
- Tibsovo-Gengraf (Cyclosporine Capsules, Modified)
- Tibsovo-Gengraf (Cyclosporine Oral Solution, Modified)
- Tibsovo-Gengraf Capsules
- Tibsovo-Gengraf Oral
- Tibsovo-Gengraf Oral Solution
- Tibsovo-Genicin