Gengraf and Vinblastine Sulfate
Determining the interaction of Gengraf and Vinblastine Sulfate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:An in vitro test has shown cyclosporine to have inhibitory effects on the biotransformation of vinblastine. Both drugs are believed to be metabolized by the liver cytochrome P-450. The clinical significance of this interaction has not been established. If cyclosporine and vinblastine are used concomitantly, caution and close observation are advised.
- Zhou-Pan XR, Seree E, Zhou XJ, et al "Involvement of human liver cytochrome P450 3A in vinblastine metabolism: drug interactions." Cancer Res 53 (1993): 5121-6
Generic Name: cyclosporine
Brand name: Gengraf, Neoral, Sandimmune, Sandimmune
Synonyms: Gengraf (Capsules, Modified)
Generic Name: vinblastine
Brand name: Velban
Synonyms: Vinblastine, VinBLAStine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Gengraf-Vincasar PFS
- Gengraf-Vincristine
- Gengraf-Vincristine (Liposomal)
- Gengraf-Vincristine Intravenous
- Gengraf-Vincristine liposome
- Gengraf-Vincristine liposome Intravenous
- Vinblastine Sulfate-Gengraf (Cyclosporine Capsules, Modified)
- Vinblastine Sulfate-Gengraf (Cyclosporine Oral Solution, Modified)
- Vinblastine Sulfate-Gengraf Capsules
- Vinblastine Sulfate-Gengraf Oral
- Vinblastine Sulfate-Gengraf Oral Solution
- Vinblastine Sulfate-Genicin