Gengraf Capsules and Pyrazinamide

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ask your doctor before using cycloSPORINE together with pyrazinamide. Using these medications together can make cycloSPORINE less effective. Given the risk of organ rejection associated with low cycloSPORINE levels, caution is advised if cycloSPORINE must be taken with pyrazinamide. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: One case report demonstrated a decrease in cyclosporine blood level of nearly 50% two days after pyrazinamide was added to the patient's drug regimen. The mechanism of this interaction is unknown.

MANAGEMENT: Cyclosporine serum concentrations should be monitored if pyrazinamide is added to or discontinued from the patient's regimen. Patients should be carefully monitored for lack of therapeutic effect. The dosage of cyclosporine may need to be increased.

Gengraf Capsules

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Gengraf (Capsules, Modified), Gengraf

What is Gengraf Capsules?

Pyrazinamide

Generic Name: pyrazinamide

Brand name:

Synonyms: n.a.

What is Pyrazinamide?