Gengraf Capsules and Rosuvastatin Sprinkle Capsules

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using cycloSPORINE together with rosuvastatin can increase your blood levels of rosuvastatin and may cause a dangerous side effect on your muscles. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely take both medications. You should also watch for muscle symptoms and call the doctor if you have muscle pain, tenderness, or weakness, especially if you also have dark colored urine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Coadministration with cyclosporine may significantly increase the plasma concentrations of rosuvastatin. The proposed mechanism is cyclosporine inhibition of the hepatic uptake of rosuvastatin via organic anion transporting polypeptide C (OATP-C). In 10 stable heart transplant patients receiving an antirejection regimen containing cyclosporine, mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of rosuvastatin (10 mg once daily for 10 days) were increased 11-fold and 7-fold, respectively, compared with historical data from 21 healthy volunteers. High levels of HMG-CoA reductase inhibitory activity in plasma is associated with an increased risk of musculoskeletal toxicity. Myopathy manifested as muscle pain and/or weakness associated with grossly elevated creatine kinase exceeding ten times the upper limit of normal has been reported occasionally. Rhabdomyolysis has also occurred rarely, which may be accompanied by acute renal failure secondary to myoglobinuria and may result in death. Rosuvastatin did not affect the plasma concentrations of cyclosporine.

MANAGEMENT: The daily dosage of rosuvastatin should not exceed 5 mg when used in combination with cyclosporine. Patients should be advised to promptly report any unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever. Rosuvastatin should be discontinued if creatine kinase is markedly elevated in the absence of strenuous exercise or if myopathy is otherwise suspected or diagnosed.

Gengraf Capsules

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Gengraf (Capsules, Modified), Gengraf

What is Gengraf Capsules?

Rosuvastatin Sprinkle Capsules

Generic Name: rosuvastatin

Brand name: Crestor, Ezallor Sprinkle

Synonyms: Rosuvastatin

What is Rosuvastatin Sprinkle Capsules?